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KMID : 0882420160910030325
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Korean Journal of Medicine
2016 Volume.91 No. 3 p.325 ~ p.329
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Severe Fever with Thrombocytopenia Syndrome Accompanied by Hemophagocytic Lymphohistiocytosis
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Kim Hyeong-Jin
Kang Lae-Hyung
Jang Jin-Ho
Kim June-Hyun
Bae Kwang-Uk
Kim Eun-Jung
Lee Su-Jin
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Abstract
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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by the SFTS virus (family Bunyaviridae, genus Phlebovirus). A 77-year-old female farmer was bitten by a tick and developed a fever 5 days later, resulting in admittance to the emergency room. The laboratory findings showed elevated liver enzyme levels, thrombocytopenia, and leukopenia. Lymphoma was suspected based on computed tomography results. After confirming SFTS virus infection via the polymerase chain reaction, a bone marrow biopsy revealed hemophagocytic lymphohistiocytosis (HLH). HLH is rarely observed in patients with SFTS and few studies have reported the presence of SFTS in bone marrow. Here, we report a case of SFTS that was initially mistaken for a lymphoma, and was accompanied by HLH.
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KEYWORD
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Severe fever with thrombocytopenia syndrome, Lymphohistiocytosis, Hemophagocytic, Lymphoma
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